May 14, 2025

Avidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virus→

May 14, 2025/ Kartik Chandran

Avidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virus

Wang et al, mBio 2025

April 27, 2025

SuFEx-enabled high-throughput medicinal chemistry for developing potent tamoxifen analogs as Ebola virus entry inhibitors (Copy)→

April 27, 2025/ Kartik Chandran

SuFEx-enabled high-throughput medicinal chemistry for developing potent tamoxifen analogs as Ebola virus entry inhibitors (Copy)

Dada et al, Front Immunol 2025

February 19, 2025

Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread→

February 19, 2025/ Kartik Chandran

Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread

Pahmeier et al, Sci Transl Med 2025

February 12, 2025

Structural insights into tecovirimat antiviral activity and poxvirus resistance→

February 12, 2025/ Kartik Chandran

Structural insights into tecovirimat antiviral activity and poxvirus resistance

Vernuccio et al, Nat Microbiol 2025

January 23, 2025

Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes→

January 23, 2025/ Kartik Chandran

Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes

McFadden et al, Cell 2024

January 15, 2025

Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning→

January 15, 2025/ Kartik Chandran

Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning

Lasso et al, Cell Host & Microbe 2025

November 15, 2024

Distinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses→

November 15, 2024/ Kartik Chandran

Distinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses

Tse et al, PLoS Pathog 2024

October 18, 2024

MPXV Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to MVA-BN Vaccination→

October 18, 2024/ Kartik Chandran

MPXV Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to MVA-BN Vaccination

Selverian et al, J Infect Dis 2024

August 27, 2024

Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogens→

August 27, 2024/ Kartik Chandran

Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogens

Nuqui et al, Nat Commun 2024

July 23, 2024

Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38→

July 23, 2024/ Kartik Chandran

Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38

Shin et al, Cell Rep 2024

July 16, 2024

A viral vaccine design harnessing prior BCG immunization confers protection against Ebola virus→

July 16, 2024/ Kartik Chandran

A viral vaccine design harnessing prior BCG immunization confers protection against Ebola virus

Ng et al, Front Immunol 2024

June 18, 2024

Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity→

June 18, 2024/ Kartik Chandran

Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity

Jing et al, Elife 2024

May 03, 2024

A VHH single-domain platform enabling discovery and development of monospecific antibodies and modular neutralizing bispecifics against SARS-CoV-2 variants→

May 03, 2024/ Kartik Chandran

A VHH single-domain platform enabling discovery and development of monospecific antibodies and modular neutralizing bispecifics against SARS-CoV-2 variants

Yang et al, Antib Ther 2024

April 11, 2024

Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies→

April 11, 2024/ Kartik Chandran

Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies

Wirchnianski et al, PLoS Pathog 2024

April 04, 2024

Case of Human Orthohantavirus Infection, Michigan, USA, 2021→

April 04, 2024/ Kartik Chandran

Case of Human Orthohantavirus Infection, Michigan, USA, 2021

Goodfellow et al, Emerg Infect Dis 2024

March 02, 2024

Broad antibody and T cell responses to Ebola, Sudan, and Bundibugyo ebolaviruses using mono- multivalent adjuvanted glycoprotein vaccines→

March 02, 2024/ Kartik Chandran

Broad antibody and T cell responses to Ebola, Sudan, and Bundibugyo ebolaviruses using mono- multivalent adjuvanted glycoprotein vaccines

Felgner et al, Antiviral Res 2024

February 07, 2024

Visualization of Early RNA Replication Kinetics of SARS-CoV-2 by Using Single Molecule RNA-FISH Combined with Immunofluorescence→

February 07, 2024/ Kartik Chandran

Visualization of Early RNA Replication Kinetics of SARS-CoV-2 by Using Single Molecule RNA-FISH Combined with Immunofluorescence

Pathak et al, Viruses 2024

January 22, 2024

Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge→

January 22, 2024/ Kartik Chandran

Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge

Hsieh C-L et al, Nat Commun 2024

July 24, 2023

Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection→

July 24, 2023/ Kartik Chandran

Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection

Slough MM et al, Nat Commun 2023

June 14, 2023

Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody→

June 14, 2023/ Kartik Chandran

Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody

Mittler E et al, Science Transl Med 2023