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  • news & media/
  • research/
  • team/
  • publications/
  • find us/
  • positions/
endocytic trafficking sketch_09_no UVRAG_Arl8b.001.png
The Chandran Lab

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The Chandran Lab
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February 09, 2016

Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway→

February 09, 2016/ Kartik Chandran
Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway

Spence JS et al, mBio 2016

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February 09, 2016/ Kartik Chandran/ Comment /Source
2016-2017, Ebola virus, membrane fusion, GP, filovirus, host factors, researchpage, 2016
June 03, 2015

Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion→

June 03, 2015/ Kartik Chandran
Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion

Kleinfelter LM, Jangra RK, Jae LT et al, MBio 2015

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June 03, 2015/ Kartik Chandran/ 1 Comment /Source
hantavirus, cholesterol, membrane fusion, host factors, genetic screen, 2014–2015, researchpage, kleinfelter2015, 2015
December 12, 2013

Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species→

December 12, 2013/ Kartik Chandran
Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species

Koellhoffer JF, Dai Z et al, J Mol Biol 2014

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December 12, 2013/ Kartik Chandran/ Comment /Source
arenavirus, CASV, GP, 2014–2015, membrane fusion, 2014
August 02, 2013

C-Peptide inhibitors of Ebola virus glycoprotein-mediated cell entry: Effects of conjugation to cholesterol and side chain-side chain cross linking→

August 02, 2013/ Kartik Chandran
C-Peptide inhibitors of Ebola virus glycoprotein-mediated cell entry: Effects of conjugation to cholesterol and side chain-side chain cross linking

Higgins CD et al, Bioorg Med Chem Lett 2013

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August 02, 2013/ Kartik Chandran/ Comment /Source
filovirus, membrane fusion, antivirals
April 19, 2013

Conformational properties of peptides corresponding to the ebolavirus GP2 membrane-proximal external region in the presence of micelle-forming surfactants and lipids→

April 19, 2013/ Kartik Chandran
Conformational properties of peptides corresponding to the ebolavirus GP2 membrane-proximal external region in the presence of micelle-forming surfactants and lipids

Regula LK, Harris R et al, Biochemistry 2013

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April 19, 2013/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, membrane fusion, GP, 2012–2013, antivirals, 2013
August 30, 2012

Crystal Structure of the Marburg virus GP2 core domain in its post-fusion conformation→

August 30, 2012/ Kartik Chandran
Crystal Structure of the Marburg virus GP2 core domain in its post-fusion conformation

Koellhoffer JF et al, Biochemistry 2012

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August 30, 2012/ Kartik Chandran/ 1 Comment /Source
2012–2013, filovirus, Ebola virus, membrane fusion, 2012
February 27, 2012

Marburg Virus Glycoprotein GP2: pH-Dependent Stability of the Ectodomain Alpha-Helical Bundle→

February 27, 2012/ Kartik Chandran
Marburg Virus Glycoprotein GP2: pH-Dependent Stability of the Ectodomain Alpha-Helical Bundle

Harrison JS et al, Biochemistry 2012

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February 27, 2012/ Kartik Chandran/ 1 Comment /Source
filovirus, Ebola virus, membrane fusion, 2012–2013, 2012
November 20, 2011

A shared immunological solution for neutralization of ebolaviruses→

November 20, 2011/ Kartik Chandran
A shared immunological solution for neutralization of ebolaviruses

Dias JM et al, Nat Struct Mol Biol 2011

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November 20, 2011/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, antibody, membrane fusion, 2010–2011
June 25, 2011

Designed protein mimics of the Ebola virus glycoprotein GP2 alpha-helical bundle: Stability and pH effects→

June 25, 2011/ Kartik Chandran
Designed protein mimics of the Ebola virus glycoprotein GP2 alpha-helical bundle: Stability and pH effects

Harrison JS, Higgins CD et al, Protein Sci 2011

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June 25, 2011/ Kartik Chandran/ 1 Comment /Source
Ebola virus, filovirus, membrane fusion, 2010–2011, 2011
May 06, 2011

Inhibition of Ebola virus entry by a C-peptide targeted to endosomes→

May 06, 2011/ Kartik Chandran
Inhibition of Ebola virus entry by a C-peptide targeted to endosomes

Miller EH, Harrison JS et al, J Biol Chem 2011

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May 06, 2011/ Kartik Chandran/ Comment /Source
filovirus, Ebola virus, membrane fusion, antivirals, 2010–2011, researchpage, 2011
January 01, 2010

A forward genetic strategy reveals destabilizing mutations in the ebolavirus glycoprotein that alter its protease dependence during cell entry→

January 01, 2010/ Kartik Chandran
A forward genetic strategy reveals destabilizing mutations in the ebolavirus glycoprotein that alter its protease dependence during cell entry

Wong AC et al, J Virol 2010

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January 01, 2010/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, cathepsin, host factors, membrane fusion, 2010–2011, researchpage, 2010

© 2015, Kartik Chandran Laboratory