Perseverance Pays Off in Fight Against Deadly Lassa Virus

Read about the quest to glimpse the molecular details of Lassa virus glycoprotein in complex with human neutralizing antibodies by our collaborators at the Saphire Lab.

The Chandran Lab’s Lara Kleinfelter helped elucidate the mode of action of the human antibodies by demonstrating inhibition of viral fusion in cells through stabilization of the pre-fusion conformation of the Lassa virus glycoprotein.